Oilinwater microemulsions for thymol solubilization mdpi. Determination of the ratio of surfactant and cosurfactant km value the cosurfactant and surfactant were in accordance with the mass ratios of 1. Throughout the article, two distinct gels, made of two different microemulsion droplets r. The phenomenon of phase inversion from wo microemulsion to ow. Ternary phase diagram basics interactive simulation.
The model drug vitamin e was loaded in the oil phase. Studies on the pseudo ternary phase diagrams of microemulsion systems and microemulsion polymerization of hpdmsmma nba. The optically transparent single phase microemulsion can be formed in the region enclosed by. Preparation and characterization of dexamethasone microemulsion. Jul 24, 2015 similar hlb values 78 with cosurfactant were favourable in order to produce a balanced microemulsion using sorbitan monolaurate crill 1 and polyoxyethylene 20 monooleate crillet 4 super 16. Pseudoternary phase diagram of microemulsion composed openi. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram. For aot systems, the effect of pressure depends on the kind of nalkane. In this study, the effect of several shortchain alcohols on pseudoternary phase diagrams. These include micelles, colloids, gels, networks, etc, and could be referred to as micellar systems. In this paper, we reported our methods based on the pseudoternary phase diagram and orthogonal design. Ternary phase diagrams were designed to determine the microemulsion region whereas facecentered ccd helped in the determination of the effect of variables. To investigate concentration range of components for the existing boundary of mes, pseudo ternary phase diagrams were constructed using the water titration method.
Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Pseudoternary phase diagrams of a drug delivery system. Studies on the pseudo ternary phase diagrams of micro. Tretinoin, phase diagram, microemulsion, differential. Interfacial tension, measurement, effect of surfactant on oilwater interface. The phase diagram also reveals the various other regions like micellar region, reverse micellar area, macroscopic emulsion ow or wo or bicontionous laminar. The effects of different surfactants pure and mixed on the mixing diagrams, especially on the. Three microemulsion formulations were prepared, of which oil, tween 20 and water were made to 100 %. Investigations into the formation and characterization of phospholipid microemulsions.
As a result, microemulsion systems may be represented as surfactantoilwater mixtures, as depicted in the pseudo ternary phase diagram 3 of figure 2. The results indicated that different amounts of surfactants and cosurfactant in the emulsion exhibited different phase behaviour in the pseudoternary phase diagram. The conductivity and viscosity studies along the dilution line in phase diagram depict the structural transition from wo to ow via bicontinuous phase at 11%. My free book expands on the content in practical surfactants but is linked to the apps so you go straight from the ebook page to the app of interest. The area covered by these points is considered as the microemulsion region of existence. Phase diagrams of wo microemulsion stabilised by nonionic. The potential drug vitamin e was loaded in the oil phase. A quaternary phase diagram is time consuming is difficult to interpret, pseudo ternary phase diagram is. It graphically depicts the ratios of the three variables as positions in an equilateral triangle. Preparation of a bisdemethoxy curcumin microemulsion. The body of the sh has a surfactantrich phase coexisting with a water and a oilrich phase, from a temperature region t. Preparation of nano and microemulsions using phase inversion.
Pseudoternary phase diagram of oil, water and surfactant showing microemulsion region. Lecithin is a natural amphiphilic molecule, the microemulsions of which are often employed as a transdermal delivery medium of drugs and cosmetics. Nanostructured microemulsion phase behavior using aot or. The cosurfactants employed were propanol and butanol, and these were used at lecithincosurfactant mixing ratios km of 1. The microemulsion region is usually characterized by constructing ternary phase diagrams. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Phase diagram phase diagram is a plot showing the condition of pressure and temperature under which two or more physical states can exist together in a state of dynamic equilibrium. Phase behavior of pseudoternary brinealkanealcohol. With that note, in this work, the phase behaviour of stable wo microemulsion regions formed by nonionic surfactants was investigated.
In order to determine the optimum formula of waterinvco microemulsion, the combinations. Research article bacterial activity of sunflower oil. Microemulsion system also enables the usage of the least expensive solvent such as water. Smallangle neutron scattering study of a pressureinduced. Effect of cosurfactant on the supramolecular structure and. Pseudoternary phase diagram were develop using aqueous titration method. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. However, it constructs a microemulsion and lamellar phase in a phase diagram without cosurfactant only at a narrow range of composition. In oilinwater type of microemulsions droplets of oil is surrounded by a surfactant and may be cosurfactant film that forms the internal phase distributed in water, which is the continuous phase.
The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. Mandal baroda college of pharmacy, vadodara, india. Phase studies have been performed for quaternary systems composed of egg lecithin, cosurfactant, water and oil. Preparation and evaluation of tretinoin microemulsion based. Topical delivery of coenzyme q10loaded microemulsion for. Microemulsion phase diagrams modelled in prof steven abbotts practical surfactants science and apps. Pseudoternary phase diagrams of systems containing waterlecithinalcohol and oil. A ccording to the size of the microemulsion area, a pseudoternary phase diagram was created to determine the microemulsion zone. Jun 15, 2012 phase diagrams indicated more width microemulsion region with a rise in sc ratio. This is the first time that the ift behavior of surfactantbrinecrude oil system is predicted based on the quantitatively characterized surfactant hydrophobicity as well as surfactant structure properties, showing the physical significance of hldnac equation of state in predicting microemulsion phase behavior. Preparation and evaluation of tretinoin microemulsion. Ternary phase diagram with phase envelope interactive simulation duration.
The pseudoternary phase diagrams of the brij 97peg 400water system using oa and ipm as the oil phase were shown in figure 1 and 2 where the shaded region represents the microemulsion region. The aim of this study was to develop a coenzyme q10 coq10 microemulsion system with improved solubility, penetration, and wound healing efficacy. At 45% wtwt surfactant system, micro emulsions containing. Pseudoternary phase diagrams of oil, water, and co. Jianzhong zhang chemical industry and ecology institute, north university of china, shanxishengtaiyuan, p. Investigations into the formation and characterization of.
Significance of co surfactants in microemulsion formulation duration. The phase diagram explorer allows you to visualise what happens when you or perhaps your customer travel a dilution path through phase diagram space. Pseudoternary phase diagram of microemulsion composed. As a result, microemulsion systems may be represented as surfactantoilwater mixtures, as depicted in the pseudoternary phase diagram 3 of figure 2. The influence of surfactantcosurfactant hydrophilic. Sep 24, 2014 pseudoternary phase diagram of oilwater brinesurfactant cosurfactant system winsortype phase behavior of microemulsion where. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. The lecithin used was the commercially available egg lecithin ovothin 200 which comprises.
The phases include conventional emulsion, gel viscous and transparenttranslucent microemulsion. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. To investigate concentration range of components for the existing boundary of mes, pseudoternary phase diagrams were constructed using the water titration method. Usually have elements at the corners as the constituents. Turbidity of the samples would indicate formation of a coarse emulsion, whereas a clear isotropic solution would indicate the formation of a microemulsion. Library utility of insilico investigations and systematic selection of components for the development of diacerein microemulsion sourabh jain and badri p. In chapter 1 a short introduction about the background, various aspects and applications. In the present work, we have studied the domain of existence of nonionic microemulsion systems within pseudoternary phase diagrams. Interfacial tension, measurement, effect of surfactant on oil. Mpde practical surfactants science prof steven abbott. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha.
The phases include conventional emulsion, gel viscous and transparent translucent microemulsion. The below shows a hypothetical ternary phase diagram of a microemulsion. A cut of the phase diagram is made at a given oilwater ratio usually. Most often pseudoternary phase diagrams are constructed to figure out microemulsion zone as quaternary phase diagram. Effects of components on and predictive modeling of. Microemulsions potential carrier for improved drug delivery. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. The pseudo ternary phase diagram and area of existence of microemulsion for tween 80ethanolcastor oilbuffer was delineated.
A detailed historical background of microemulsions can be found elsewhere 25. Phase behaviour of an ionic microemulsion system as a function of. The critical points between microemulsion region and other phase regions were determined when the appearance of the system changed from clear to turbid, and vice versa. Pseudoternary phase diagrams of systems containing waterlecithinisopropyl myristate and either an alkanoic acid, amine, alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant. According to the infinite dilution region of the best phase diagram, the best ratio among o, s and w phases for preparing the bisdemethoxy curcumin microemulsion was a weight ratio of 4. Oillipid based formulations have been developed in the past by using phase diagrams.
It seems that the effect of pg as cosurfactant in mes release profile may be as retardant, since with decrease in sc ratio and water and increase in oil phase ratio could be obtained high in vitro percentage release. Optimum formula of wo micmemulsion the microemulsion system can be formulated by appropriate proportions of water, surfactants, and oil. Emulsions part 3 microemulsions miniemulsions remarks to. It is used in physical chemistry, petrology, mineralogy, metallurgy, and other physical sciences to show the compositions of systems. To identify regions like ow microemulsion or nanoemulsion, coarse emulsions and gelviscous by dissolving spe. Three components are the basic requirement to form a microemulsion. Although, the pseudoternary phase method has been employed to preparation of microemulsion, the combination method of the pseudoternary phase diagram and the orthogonal desi gn has rarely been reported. Preparation and evaluation of tretinoin microemulsion based on pseudo ternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Phase diagram construction is practical approach to study complex series of interaction which occurs when different components are mixed. Application of ternar phase diagrams in pharmaceutical research journal of young pharmacists, vol 10, issue 2, aprjun, 2018 3 of perpendicular lines rather straight lines are drawn from each vertex or corner, to the opposite side of the triangle passing through the point. Characterization of microemulsions prepared using isopropyl. Oil, water and surfactants are mixed, microemulsions are the one of the number of association structures including emulsion, lamellar, micelles, cubic and hexagonal that can form depending up on the composition. A hypothetical phase diagram of a microemulsion given by prince 1977 is shown in fig. Prepare 500 ml stock solution from one of the surfa.
Stability tests showed that all the indicators of our prepared microemulsion met. How can i construct a ternary phase diagram for microemulsion. Phase behavior of ionic microemulsions utrecht university. Characterization of microemulsion structures in the. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. May 30, 2015 theories of microemulsion formation 19 complex film formation at interface due to cosurf. Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudo component. Take a wo microemulsion of, say, barium chloride and mix it with a wo microemulsion of, say, sodium sulfate, the two react to create nanoparticles of insoluble baso4. For this reason frequently cuts through the phase diagram are presented, for example at constant watertooil ratio or constant surfactanttocosurfactant ratio. The results indicated that different amounts of surfactants and cosurfactant in the emulsion exhibited different phase behaviour in the pseudo ternary phase diagram. Ternary phase diagrams institute for advanced study. Uses a simulation to show how ternary phase diagrams are interpreted.
Formulation and characterization of microemulsion based gel. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Oil water surfactant and co surfactant the concentration of co surfactant is varied. L2 and lc represent the reversed micelle and the liquid crystal respectively. A pseudoternary phase diagram was constructed using water titration method. Pseudoternary phase diagrams of water, oil and s smix of. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Because of the unusual shape of the wo region, the alteration of the wo droplets to a cylindrical form, along a line of fixed concentration of surfactant traverses a region in which a microemulsion cannot be thermodynamically stable.
This is for a single phase, three component system. Predicting microemulsion phase behavior using physics based. Multicomponent phase diagrams are generally based on constant ratios of surfactant to water or cosurfactanttosurfactant 1. A cut through the phase diagram in the temperatureesurfactant concentration plane at an oiltowater ratio of about unity displays a characteristic. Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudocomponent. Characterization of microemulsion structures in the pseudoternary. Formula optimization design of pesticide microemulsion. However, the pseudo ternary plot is a convenient mean of determining the compositions of microemulsion, macroemulsion and. Effects of components on and predictive modeling of microemulsion phase behavior in nonionic systems prapaporn boonme 1, chalida boonthongchuay, thanaporn amnuaikit2 and wibulwongpoowarak2 1department of pharmaceutical technology and nanotecpsu center of excellence on drug delivery system, faculty of pharmaceutical sciences, prince. The influence of drug loading level on the phase diagram was also determined. Each corner of the ternary phase diagram represents 100% concentrations of a particular component. Design and formulation of optimized microemulsions for dermal. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity.
Read investigations into the formation and characterization of phospholipid microemulsions. Its phase diagram can be used as a guide for the selection of different microemulsion compositions for hydrothermal synthesis. The aim of the present research was to formulate a transparent microemolsion as a topical delivery system for tretinoin for the treatment of acne. The microemulsion regions were defined as ow or ow type according to oil and water weight ratios. Microemulsion formulations prepared by mixing appropriate amount of surfactant including tween 80 and labrasol, cosurfactant such as propylene glycol pg and oil phase including isopropyl myristate transcutol p 10.
Enlargement of nanoemulsion region in pseudoternary. The influence of oil, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The aspect of the phase diagram is phase equilibrium and demarcation of phase boundaries. The size area of the microemulsion region of the phase diagram was found to be. Pseudo ternary diagrams of pesticide microemulsion systems. Slow titration with aqueous phase was done to each weight ratio of oil and smix and visual observation was carried out for transparent and easily flow able oil in water nano emulsion. Formulation of agrochemical microemulsion is not a straightforward process. Evaluation and optimization of waterinoil microemulsion using. The samples were centrifuged at 8000 rpm for 10 minutes and the drug content in the supernatant was analysed after proper dilution with methanol as described in. This may be proving better stability and release of. When four or more components are used pseudoternary phase.
It can be downloaded for ibooks, for the ipad, for kindle and as pdf. A fundamental reason for the uses of these systems is that a microemulsion phase sometimes has an ultralow interfacial tension with a separate oil or aqueous phase, which may release or mobilize them from solid phases even in conditions of slow flow or low pressure gradients. Nanostructured microemulsion phase behavior using aot or extended surfactant combined with a cationic hydrotrope 55. Formulation and characterization of microemulsion system. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Ternary phase diagram of a system aotwater heptane at 25. Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region. Preparation, optimization and characterization of microemulsions 169 to different oils, surfactants and cosurfactants and stirred on magnetic stirrer for 24 hours.
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